The 21st Meeting of the Parties to the Montreal Protocol will be held in November 2009 in Egypt. The climate issue will take up much of the agenda. A proposal to regulate greenhouse gases, which are linked to the phase-out of ozone-depleting substances, will be discussed. An important aspect is to develop green alternatives to CFCs. How ozone-depleting substances in old equipment, insulation material, etc., shall be disposed of globally is another issue on the agenda. Unless these substances are collected and destroyed, they risk being released into the atmosphere, especially in developing countries. The 1 January 2010 is a milestone in the history of the Montreal Protocol since it marks the total phase-out of hard CFCs and several other ozone-depleting substances even in developing countries. The Meeting of the Parties must adopt certain exemptions from the ban, however, to safeguard access to medicines in these countries.